Endometrial cancer Essay Example | Topics and Well Written Essays - 2500 words

Endometrial cancer - Essay Example The most common type of endometrial cancer is endometrioid adenocarcinoma. It is developed in cells that form glands of the endometrium and shows specific features under the microscope. Endometrioid endometrial cancer (EEC) is the most common type of endometrial cancer, which compromises about 75% to 80% of endometrial cancer and usually occurs at the time of, or one to two decades after menopause, and shows most common symptoms with vaginal bleeding. Its clinical behaviour and grade depend on the degree of differentiation. High grade of tumour development are associated with more advanced stage of disease. Endometrial subtype of endometrial cancer (EEC) is estrogen related. It is already well defined that high level of estrogen in patients lead to increase the risk of endometrial adenocarcinoma as estrogen hormone sustains to promote the growth of endometrial cancer cells. That is, the risk of tumour development is associated with an increase in uncontrolled estrogen activity. According to the study of classic model regarding endometrial cancer and breast cancer, estrogen modulates the expression of estrogen responsive downstream effectors by binding to estrogen receptor and induces subsequent reactions through the action of estrogen receptor at the transcriptional level. The second most common form is papillary serous adenocarcinoma, which is composed of about 10% of all endometrial cancers and another form is clear cell adenocarcinoma, which compromises about 4-5% of all endometrial carcinomas. Both papillary serous and clear cell adenocarcinomas show more aggressiveness than endo metrioid adenocarcinomas, and can be often detected at advanced stages. Estrogen hormone functions on cell growth and differentiation, mainly in tissues of reproductive system including mammary glands, uterus, vagina and ovaries in female and testis,